Sick Fat Cells May Lead to Type 2 Diabetes


New research from Temple University School of Medicine suggests that overweight and obese people may have less healthy fat cells than people who don’t carry extra weight, which is one correlation that may further explain the connection between some obese people and type 2 diabetes (not all overweight or obese people develop type 2 diabetes or are clinically unhealthy).

Scientists studied fat cells found it the thighs of volunteers, found that the cells from obese subjects were not as efficient as those found the slimmer control group. The results lead researchers to label these non-functioning cells as “sick,” because they simply don’t work the way properly.

“The fat cells we found in our obese patients were deficient in several areas,” said Guenther Boden, MD, Professor of Medicine and Chief of Endocrinology in a press release. “They showed significant stress on the endoplasmic reticulum, and the tissue itself was more inflamed than in our lean patients.”

Protein synthesis is one of the important functions of fat cells.  If these cells become stressed due to obesity, the part of the cell responsible for protein synthesis (called the endoplasmic reticulum) malfunction. As a result, insulin resistance and type 2 diabetes may sometimes follow.

Adopting a healthy lifestyle program to bring about healthy weight loss may help lower the stress on fat cells, and – ultimately – lower the risk of type 2 diabetes.

For related information, read “Identification Of Protein That Produces ‘Good’ Fat, Has Potential To Treat, Prevent Obesity.”

2 responses to “Sick Fat Cells May Lead to Type 2 Diabetes”

  1. Very interesting stuff…did you see the latest study on fat and HFCS? This study makes me think of that one…

  2. Benny says:

    Nice site 🙂

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